ZFIN ID: ZDB-GENE-040426-2308
Gene Name: SIX homeobox 1b
Gene Symbol: six1b
Previous Names: six1 (1), six1a (1), zgc:77345 (1)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 30 figures from 12 publications
Directly Submitted Expression Data: 6 figures (28 images) from Thisse et al., 2004 [MGC:77345]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  adductor hyohyoid, adductor mandibulae, adductor operculi, adenohypophyseal placode (all 46) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fr15 Point Mutation Unknown Stop Loss ENU
fr16 Point Mutation Unknown Unknown
sa10473 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-six1b (1), MO2-six1b (1), MO3-six1b (1), MO4-six1b (1), MO5-six1b (1)
    PHENOTYPE
    Data: 12 figures from 5 publications
    Observed in: adrenocorticotropic hormone secreting cell, cephalic musculature skeletal muscle tissue development, fast muscle cell muscle fiber development, fast muscle cell myofibril (all 20) expand
    DISEASE ASSOCIATED WITH six1b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness Deafness, autosomal dominant 23 605192
    branchiootic syndrome Branchiootic syndrome 3 608389
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR031278 (1)
  • InterPro:IPR031701 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF16878 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA six1b-001 (1) 5417
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM six1b
    Tg(six1b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    six1bContained in: [BAC] DKEY-225H23 (1) (order this)
    six1bEncodes: [cDNA] MGC:77345 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207095 (1) 1276bp
    Genomic GenBank:BX649231 (1) 153569bp
    Select Tool
    Polypeptide UniProtKB:Q6NZ04 (1) 284aa
    Sequence Clusters UniGene:27681 (1)
    Sequence Information (all 18)
    OTHER six1b GENE PAGES
  • Gene:404627 (1)
  • VEGA:OTTDARG00000004934 (1)
  • Ensembl(GRCz10):ENSDARG00000026473 (1)
  • ORTHOLOGY for six1b (Chr: 20)
    Species Symbol Chromosome Accession # Evidence
    Human SIX1 14
  • Gene:6495
  • OMIM:601205
  • HGNC:10887
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Phylogenetic tree (1)
    Mouse Six1 12
  • MGI:102780
  • Gene:20471
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (35)