Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-2308
Gene Name: SIX homeobox 1b
Gene Symbol: six1b
Previous Names: six1 (1), six1a (1), zgc:77345 (1)
Location: Chr: 20   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 29 figures from 11 publications
Directly Submitted Expression Data: 6 figures (28 images) from Thisse et al., 2004 [MGC:77345]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  adductor hyohyoid, adductor mandibulae, adductor operculi, adenohypophyseal placode (all 43) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 genotypes
Alleles: fr15, fr16, sa10473
Knockdown reagents: MO1-six1b (1), MO2-six1b (1), MO3-six1b (1), MO4-six1b (1), MO5-six1b (1)
PHENOTYPE
Data: 12 figures from 5 publications
Observed in: adrenocorticotropic hormone secreting cell, cephalic musculature skeletal muscle tissue development, fast muscle cell muscle fiber development, fast muscle cell myofibril (all 21) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Brachiootic syndrome 3 608389
Deafness, autosomal dominant 23 605192
GENE ONTOLOGY
Ontology GO Term
Biological Process adenohypophysis development (more)
Cellular Component cytoplasm (more)
Molecular Function DNA binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA six1b-001 (1) 5417
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM six1b
    Tg(six1b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    six1b Contained in: [BAC] DKEY-225H23 (1)
    six1b Encodes: [cDNA] MGC:77345 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207095 (1) 1276 bp
    Genomic GenBank:BX649231 (1) 153569 bp
    Select Tool
    Polypeptide UniProtKB:Q6NZ04 (1) 284 aa
    Sequence Clusters UniGene:27681 (1)
    Sequence Information (all 18)
    OTHER six1b GENE PAGES
  • Gene:404627 (1)
  • VEGA:OTTDARG00000004934 (1)
  • Ensembl(Zv9):ENSDARG00000026473 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish six1b 20  
    Human SIX1 14 (14q23.1)
  • OMIM:601205
  • Gene:6495
  • Mouse Six1 12 ( 30.34 cM)
  • MGI:102780
  • Gene:20471
  • Orthology Details
    CITATIONS (31)