Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-2308
Gene Name: sine oculis homeobox homolog 1b
Gene Symbol: six1b
Previous Names: six1 (1), six1a (1), zgc:77345 (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 20 figures from 7 publications
Directly Submitted Expression Data: 6 figures (28 images) from Thisse et al., 2004 [MGC:77345]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  adductor hyohyoid, adductor mandibulae, adductor operculi, adenohypophyseal placode (all 38) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 genotypes
Alleles: fr15, fr16, sa10473
Knockdown reagents: MO1-six1b (1), MO2-six1b (1), MO3-six1b (1), MO4-six1b (1), MO5-six1b (1)
PHENOTYPE
Data: 9 figures from 3 publications
Observed in: adrenocorticotropic hormone secreting cell, fast muscle cell myofibril, fast muscle cell, hypobranchial muscle (all 16) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Brachiootic syndrome 3 608389
Deafness, autosomal dominant 23 605192
GENE ONTOLOGY
Ontology GO Term
Biological Process adenohypophysis development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA six1b-001 (1) 1317
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM six1b No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    six1b Contained in: [BAC] DKEY-225H23 (1) (order this)
    six1b Encodes: [cDNA] MGC:77345 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207095 (1) 1276 bp
    Genomic GenBank:BX649231 (1) 153569 bp
    Select Tool
    Polypeptide UniProtKB:Q6NZ04 (1) 284 aa
    Sequence Clusters UniGene:27681 (1)
    Sequence Information (all 18)
    OTHER six1b GENE PAGES
  • Gene:404627 (1)
  • VEGA:OTTDARG00000004934 (1)
  • Ensembl(Zv9):ENSDARG00000026473 (1)
  • MAPPING INFORMATION
    Chr: 20 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish six1b 20  
    Human SIX1 14 (14q23.1)
  • OMIM:601205
  • Gene:6495
  • Mouse Six1 12 ( 30.34)
  • MGI:102780
  • Gene:20471
  • CITATIONS (25)