Gene
otulina
- ID
- ZDB-GENE-040426-2157
- Name
- OTU deubiquitinase with linear linkage specificity a
- Symbol
- otulina Nomenclature History
- Previous Names
-
- fam105ba
- wu:fj43e01
- zgc:64095
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in protein linear deubiquitination. Predicted to colocalize with LUBAC complex. Human ortholog(s) of this gene implicated in otulipenia. Is expressed in alar plate midbrain region; lens; optic tectum; retina; and solid lens vesicle. Orthologous to several human genes including YAE1 (YAE1 maturation factor of ABCE1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64095 (4 images)
- IMAGE:6909406 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Cheung et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| otulipenia | Alliance | Autoinflammation, panniculitis, and dermatosis syndrome | 617099 |
| {Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection} | 619986 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Essential protein Yae1, N-terminal | Yae1-like |
|---|---|---|---|
|
UniProtKB:Q7T354
|
220 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
otulina-205
(1)
|
Ensembl | 931 nt | ||
| mRNA |
otulina-201
(1)
|
Ensembl | 1,268 nt | ||
| mRNA |
otulina-202
(1)
|
Ensembl | 535 nt | ||
| mRNA |
otulina-204
(1)
|
Ensembl | 3,081 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance