Gene

galcb

ID

ZDB-GENE-040426-2115

Name

galactosylceramidase b

Symbol

galcb Nomenclature History

Previous Names

wu:fi04e07
zgc:56444

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Exhibits galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Localizes to lysosome. Human ortholog(s) of this gene implicated in Krabbe disease. Is expressed in central nervous system; cerebellum; hindbrain; midbrain; and midbrain hindbrain boundary. Orthologous to human GALC (galactosylceramidase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56444 (1 image)
IMAGE:7158422 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Belleri et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With galcb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Krabbe disease	Alliance	Krabbe disease	245200

Associated With galcb Via Experimental Models

Human Disease	Fish	Conditions	Citations
melanoma	AB + MO1-galcb	standard conditions	Belleri et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR035394	Glycosyl hydrolase family 59, central domain
Domain	IPR049161	Glycosyl hydrolase family 59, catalytic domain
Domain	IPR049162	Glycosyl hydrolase family 59, C-terminal lectin domain
Family	IPR001286	Glycoside hydrolase, family 59
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR017853	Glycoside hydrolase superfamily