Gene

got1

ID

ZDB-GENE-040426-2003

Name

glutamic-oxaloacetic transaminase 1, soluble

Symbol

got1 Nomenclature History

Previous Names

wu:fj63b09
zgc:55996

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to act upstream of or within amino acid metabolic process and biosynthetic process. Predicted to be active in cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With got1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Aspartate aminotransferase, serum level of, QTL1	614419

Associated With got1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR004838	Aminotransferases, class-I, pyridoxal-phosphate-binding site
Domain	IPR004839	Aminotransferase, class I/classII, large domain
Family	IPR000796	Aspartate/other aminotransferase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase

Domain Details Per Protein

Protein	Length	Aminotransferase, class I/classII, large domain	Aminotransferases, class-I, pyridoxal-phosphate-binding site	Aspartate/other aminotransferase	Pyridoxal phosphate-dependent transferase	Pyridoxal phosphate-dependent transferase, major domain	Pyridoxal phosphate-dependent transferase, small domain
UniProtKB:Q7ZUW8 InterPro	410

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	got1-201 (1) Ensembl	Ensembl	666 nt	Select Tool ZFIN BLAST
mRNA	got1-204 (1) Ensembl	Ensembl	3,260 nt	Select Tool ZFIN BLAST
ncRNA	got1-002 (1) Ensembl	Ensembl	539 nt	Select Tool ZFIN BLAST
ncRNA	got1-003 (1) Ensembl	Ensembl	819 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations