Gene
cstf3
- ID
- ZDB-GENE-040426-1997
- Name
- cleavage stimulation factor, 3' pre-RNA, subunit 3
- Symbol
- cstf3 Nomenclature History
- Previous Names
-
- cleavage stimulation factor, 3 pre-RNA, subunit 3
- wu:fa99c02
- wu:fb18b09
- zgc:56028
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be involved in RNA 3'-end processing. Predicted to act upstream of or within mRNA 3'-end processing. Predicted to be active in nucleus. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137479 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2908Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la020481Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa16073 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16190 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32217 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t25877 | Allele with one point mutation | Unknown | Frameshift | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | HAT (Half-A-TPR) repeat | mRNA 3'-end-processing protein Rna14-like | Suppressor of forked | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZVG5
|
716 | ||||
|
UniProtKB:F1QIB2
|
716 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-34O23 | ZFIN Curated Data | |
| Contains | SNP | rs3728934 | ZFIN Curated Data | |
| Encodes | EST | fa99c02 | ZFIN Curated Data | |
| Encodes | EST | fb18b09 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7137479 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56028 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192738 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213053 (1) | 2702 nt | ||
| Genomic | GenBank:CU896647 (1) | 118597 nt | ||
| Polypeptide | UniProtKB:F1QIB2 (1) | 716 aa |
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Feiner, N., Meyer, A., Kuraku, S. (2014) Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. Genome biology and evolution. 6(7):1635-51
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Bai, X., Kim, J., Yang, Z., Jurynec, M.J., Akie, T.E., Lee, J., LeBlanc, J., Sessa, A., Jiang, H., DiBiase, A., Zhou, Y., Grunwald, D.J., Lin, S., Cantor, A.B., Orkin, S.H., and Zon, L.I. (2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142(1):133-143
- Klüver, N., Herpin, A., Braasch, I., Driessle, J., and Schartl, M. (2009) Regulatory back-up circuit of medaka Wt1 co-orthologs ensures PGC maintenance. Developmental Biology. 325(1):179-188
- Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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