Gene
hmox1b
- ID
- ZDB-GENE-040426-1807
- Name
- heme oxygenase 1b
- Symbol
- hmox1b Nomenclature History
- Previous Names
-
- zgc:77234 (1)
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Is expressed in several structures, including digestive system; gill; solid lens vesicle; vein; and visual system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1).
- Genome Resources
-
- Alliance (1)
- Gene:402970 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77234 (3 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic obstructive pulmonary disease | Alliance | {Pulmonary disease, chronic obstructive, susceptibility to} | 606963 |
| Heme oxygenase-1 deficiency | 614034 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
- No data available
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Dixon, S.C., Calder, B.J., Lilya, S.M., Davies, B.M., Martin, A., Peterson, M., Hansen, J.M., Suli, A. (2022) Valproic acid affects neurogenesis during early optic tectum development in zebrafish. Biology Open. 12(1):
- Luo, K., Ogawa, M., Ayer, A., Britton, W.J., Stocker, R., Kikuchi, K., Oehlers, S.H. (2022) Zebrafish Heme Oxygenase 1a Is Necessary for Normal Development and Macrophage Migration. Zebrafish. 19(1):7-17
- An, J., Cheng, L., Yang, L., Song, N., Zhang, J., Ma, K., Ma, J. (2021) P- Hydroxybenzyl Alcohol Alleviates Oxidative Stress in a Nonalcoholic Fatty Liver Disease Larval Zebrafish Model and a BRL-3A Hepatocyte Via the Nrf2 Pathway. Frontiers in pharmacology. 12:646239
- Luo, K., Stocker, R., Britton, W.J., Kikuchi, K., Oehlers, S.H. (2021) Heme oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish. The FEBS journal. 289(3):671-681
- Holowiecki, A., O'Shields, B., Jenny, M.J. (2016) Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicology and applied pharmacology. 311:74-87
- Fuse, Y., Nakajima, H., Nakajima-Takagi, Y., Nakajima, O., Kobayashi, M. (2015) Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes to cells : devoted to molecular & cellular mechanisms. 20(7):590-600
- Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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