Gene

fhit

ID
ZDB-GENE-040426-1703
Name
fragile histidine triad diadenosine triphosphatase
Symbol
fhit Nomenclature History
Previous Names
  • zgc:73176
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have bis(5'-adenosyl)-triphosphatase activity. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fhit Human Ortholog
No data available
Associated With fhit Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019808 Histidine triad, conserved site
Domain IPR011146 HIT-like domain
Family IPR039383 FHIT family
Family IPR052677 Dinucleoside polyphosphate hydrolase
Homologous_superfamily IPR036265 HIT-like superfamily
Domain Details Per Protein
Protein Length Dinucleoside polyphosphate hydrolase FHIT family Histidine triad, conserved site HIT-like domain HIT-like superfamily
UniProtKB:Q6PBZ7 150
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fhit-201 (1) Ensembl 1,350 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations