Gene
sars2
- ID
- ZDB-GENE-040426-1616
- Name
- seryl-tRNA synthetase 2, mitochondrial
- Symbol
- sars2 Nomenclature History
- Previous Names
-
- zgc:66345 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable serine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to act upstream of or within seryl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66345 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis | 613845 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR033729 | Serine-tRNA ligase catalytic core domain |
| Family | IPR002317 | Serine-tRNA ligase, type1 |
| Homologous_superfamily | IPR010978 | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Serine-tRNA ligase catalytic core domain | Serine-tRNA ligase, type1 | Serine-tRNA synthetase, type1, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AID0 | InterPro | 282 | |||||||
| UniProtKB:Q7SXG8 | InterPro | 510 | |||||||
| UniProtKB:A0A8M3B0U6 | InterPro | 494 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-260J18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66345 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201179 (1) | 1815 nt | ||
| Genomic | GenBank:CR388387 (1) | 138115 nt | ||
| Polypeptide | UniProtKB:Q7SXG8 (1) | 510 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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