Gene

mtap

ID

ZDB-GENE-040426-1505

Name

methylthioadenosine phosphorylase

Symbol

mtap Nomenclature History

Previous Names

zgc:66012

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to act upstream of or within purine ribonucleoside salvage. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66012 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mtap Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
diaphyseal medullary stenosis with malignant fibrous histiocytoma	Alliance	Diaphyseal medullary stenosis with malignant fibrous histiocytoma	112250

Associated With mtap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018099	Purine phosphorylase, family 2, conserved site
Domain	IPR000845	Nucleoside phosphorylase domain
Family	IPR010044	Methylthioadenosine phosphorylase (MTAP)
Homologous_superfamily	IPR035994	Nucleoside phosphorylase superfamily