Gene
tsc22d3
- ID
- ZDB-GENE-040426-1433
- Name
- TSC22 domain family, member 3
- Symbol
- tsc22d3 Nomenclature History
- Previous Names
-
- gilz (1)
- zgc:65831
- zgc:77028
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Acts upstream of or within brain development; dorsal/ventral pattern formation; and positive regulation of BMP signaling pathway. Is expressed in regenerating fin. Orthologous to human TSC22D3 (TSC22 domain family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Tse et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tsc22d3 | N/A | Tse et al., 2013 |
| MO2-tsc22d3 | N/A | Tse et al., 2013 |
| MO3-tsc22d3 | N/A | Manesia et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TSC22/Bun | TSC22/Bun, conserved site |
|---|---|---|---|
|
UniProtKB:Q6NTI0
|
143 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tsc22d3-201
(1)
|
Ensembl | 1,684 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220E11 | ZFIN Curated Data | |
| Encodes | EST | fd58e04 | ||
| Encodes | cDNA | MGC:65831 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77028 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC068985 (1) | 1795 nt | ||
| Genomic | GenBank:AL954136 (1) | 194869 nt | ||
| Polypeptide | UniProtKB:Q6NTI0 (1) | 143 aa |
- Hoppstädter, J., Valbuena Perez, J.V., Linnenberger, R., Dahlem, C., Legroux, T.M., Hecksteden, A., Tse, W.K.F., Flamini, S., Andreas, A., Herrmann, J., Herr, C., Müller, R., Meyer, T., Bals, R., Riccardi, C., Bruscoli, S., Kiemer, A.K. (2020) The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(3):4684-4701
- Faltermann, S., Hettich, T., Küng, N., Fent, K. (2019) Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 218:105372
- Garland, M.A., Sengupta, S., Mathew, L.K., Truong, L., de Jong, E., Piersma, A.H., La Du, J., Tanguay, R.L. (2019) Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology reports. 6:529-537
- Willi, R., Castiglioni, S., Salgueiro Gonzalez, N., Furia, N., Mastroianni, S., Faltermann, S., Fent, K. (2019) Physiological and transcriptional effects of mixtures of environmental estrogens, androgens, progestins and glucocorticoids in zebrafish. Environmental science & technology. 54(2):1092-1101
- Willi, R.A., Salgueiro-González, N., Carcaiso, G., Fent, K. (2019) Glucocorticoid mixtures of fluticasone propionate, triamcinolone acetonide and clobetasol propionate induce additive effects in zebrafish embryos. Journal of hazardous materials. 374:101-109
- Willi, R.A., Salgueiro-González, N., Faltermann, S., Hettich, T., Fent, K. (2019) Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. The Science of the total environment. 672:183-191
- Zheng, M., Lu, J., Zhao, D. (2018) Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Scientific Reports. 8:8083
- Manesia, J.K., Franch, M., Tabas-Madrid, D., Nogales-Cadenas, R., Vanwelden, T., Van Den Bosch, E., Xu, Z., Pascual-Montano, A., Khurana, S., Verfaillie, C. (2017) Distinct molecular signature of murine fetal liver and adult hematopoietic stem cells identifies novel regulators of hematopoietic stem cell function. Stem cells and development. 26(8):573-584
- Tsachaki, M., Meyer, A., Weger, B., Kratschmar, D.V., Tokarz, J., Adamski, J., Belting, H.G., Affolter, M., Dickmeis, T., Odermatt, A. (2017) Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. The Journal of endocrinology. 232(2):323-335
- Vettori, A., Greenald, D., Wilson, G.K., Peron, M., Facchinello, N., Markham, E., Sinnakaruppan, M., Matthews, L.C., McKeating, J.A., Argenton, F., van Eeden, F.J.M. (2017) Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. Proceedings of the National Academy of Sciences of the United States of America. 114(37):9948-9953
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