Gene
cisd2
- ID
- ZDB-GENE-040426-1381
- Name
- CDGSH iron sulfur domain 2
- Symbol
- cisd2 Nomenclature History
- Previous Names
-
- zgc:64148
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Predicted to be involved in autophagy of mitochondrion; multicellular organism aging; and regulation of autophagy. Predicted to localize to endoplasmic reticulum membrane and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64148 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Wolfram syndrome 2 | Alliance | Wolfram syndrome 2 | 604928 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CDGSH iron-sulfur domain-containing protein 1/2 | Iron-binding zinc finger, CDGSH type | Iron sulphur domain-containing, mitoNEET, N-terminal | MitoNEET, CDGSH iron-sulfur domain |
|---|---|---|---|---|---|
|
UniProtKB:Q7T326
|
135 |
Interactions and Pathways
No data available
Plasmids
No data available