Gene
arrb2b
- ID
- ZDB-GENE-040426-1332
- Name
- arrestin, beta 2b
- Symbol
- arrb2b Nomenclature History
- Previous Names
-
- arrb2
- ARRB2b2 (1)
- zgc:64007
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable angiotensin receptor binding activity. Acts upstream of or within muscle organ development; regulation of receptor recycling; and regulation of signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; axis; brain; vasculature; and ventral mesoderm. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64007 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025918Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa38610 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40890 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-arrb2b | N/A | (5) |
| MO2-arrb2b | N/A | Mahabaleshwar et al., 2012 |
| MO3-arrb2b | N/A | Mahabaleshwar et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Arrestin | Arrestin, conserved site | Arrestin C-terminal-like domain | Arrestin-like, C-terminal | Arrestin-like, N-terminal | Arrestin, N-terminal | Immunoglobulin E-set |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AU12
|
334 | |||||||
|
UniProtKB:A0A8M3B109
|
420 | |||||||
|
UniProtKB:A0A8M3B3X5
|
420 | |||||||
|
UniProtKB:Q7T2D2
|
408 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arrb2b-201
(1)
|
Ensembl | 4,613 nt | ||
| ncRNA |
arrb2b-002
(1)
|
Ensembl | 719 nt | ||
| ncRNA |
arrb2b-003
(1)
|
Ensembl | 636 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6N21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64007 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191683 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201124 (1) | 2656 nt | ||
| Genomic | GenBank:BX005022 (1) | 217582 nt | ||
| Polypeptide | UniProtKB:A0A8M3B109 (1) | 420 aa |
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Qian, Y., Ji, C., Yue, S., Zhao, M. (2019) Exposure of low-dose fipronil enantioselectively induced anxiety-like behavior associated with DNA methylation changes in embryonic and larval zebrafish. Environmental pollution (Barking, Essex : 1987). 249:362-371
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kossack, M., Hein, S., Juergensen, L., Siragusa, M., Benz, A., Katus, H.A., Most, P., Hassel, D. (2017) Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. Journal of Molecular and Cellular Cardiology. 108:95-105
- Li, Y., Du, X., Pei, G., Du, J., Zhao, J. (2016) β-Arrestin1 Regulates Morphology and Dynamics of Microglia in Zebrafish in Vivo. The European journal of neuroscience. 43(2):131-8
- Burczyk, M.S., Burkhalter, M.D., Blätte, T., Matysik, S., Caron, M.G., Barak, L.S., Philipp, M. (2015) Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2. Biochemistry. 54(3):765-75
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ferreira, T., Wilson, S.R., Choi, Y.G., Risso, D., Dudoit, S., Speed, T.P., Ngai, J. (2014) Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron. Neuron. 81(4):847-59
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Mahabaleshwar, H., Tarbashevich, K., Nowak, M., Brand, M., and Raz, E. (2012) beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation. Development (Cambridge, England). 139(16):2897-2902
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