Gene

cyp7a1

ID

ZDB-GENE-040426-1296

Name

cytochrome P450, family 7, subfamily A, polypeptide 1

Symbol

cyp7a1 Nomenclature History

Previous Names

cyp7a1
cyp7a1a
zgc:63920 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cellular response to glucose stimulus and cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in basal plate midbrain region; central nervous system; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu2450 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp7a1 Human Ortholog

No data available

Associated With cyp7a1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002403	Cytochrome P450, E-class, group IV
Family	IPR024204	Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
Family	IPR030681	Cholesterol 7-alpha-monooxygenase
Family	IPR050529	Cytochrome P450, sterol 14-alpha demethylase
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily