Gene

rars2

ID

ZDB-GENE-040426-1244

Name

arginyl-tRNA synthetase 2, mitochondrial

Symbol

rars2 Nomenclature History

Previous Names

zgc:63702

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have arginine-tRNA ligase activity. Involved in brain morphogenesis. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:63702 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Kasher et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 6	Alliance	Pontocerebellar hypoplasia, type 6	611523

Associated With rars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Domain	IPR008909	DALR anticodon binding
Domain	IPR035684	Arginyl-tRNA synthetase, catalytic core domain
Family	IPR001278	Arginine-tRNA ligase
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

Domain Details Per Protein

Protein	Length	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding	Aminoacyl-tRNA synthetase, class I, conserved site	Arginine-tRNA ligase	Arginyl-tRNA synthetase, catalytic core domain	DALR anticodon binding	Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:Q6PGW8 InterPro	597
UniProtKB:A0A8M3AVZ0 InterPro	577

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	rars2-203 (1) Ensembl	Havana	882 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rars2-201 (1) Ensembl	Havana	1942 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rars2-202 (1) Ensembl	Havana	881 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations