Gene
cdc14aa
- ID
- ZDB-GENE-040426-1214
- Name
- cell division cycle 14Aa
- Symbol
- cdc14aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Acts upstream of or within cilium assembly. Located in centrosome and spindle pole. Is expressed in Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pronephric duct. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63654 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| idc14 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| sa8511 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15795 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19671 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdc14aa | Imtiaz et al., 2017 | |
| MO1-cdc14aa | N/A | Clément et al., 2012 |
| MO2-cdc14aa | N/A | Clément et al., 2012 |
| MO3-cdc14aa | N/A | Delmaghani et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 32 | Alliance | Deafness, autosomal recessive 32, with or without immotile sperm | 608653 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Domain | IPR029260 | Dual specificity/tyrosine protein phosphatase, N-terminal |
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Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual-specificity phosphatase CDC14, C-terminal | Dual specificity protein phosphatase domain | Dual specificity/tyrosine protein phosphatase, N-terminal | Protein Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BAA8
|
468 | ||||||||
|
UniProtKB:Q7SXZ4
|
592 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdc14aa-201
(1)
|
Ensembl | 2,562 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-60B12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63654 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201149 (1) | 2205 nt | ||
| Genomic | GenBank:AL953893 (1) | 216749 nt | ||
| Polypeptide | UniProtKB:Q7SXZ4 (1) | 592 aa |
- Li, X., Yang, S., Zhang, X., Zhang, Y., Zhang, Y., Li, H. (2024) Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System. International Journal of Molecular Sciences. 25(11):
- Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:
- Imtiaz, A., Belyantseva, I.A., Beirl, A.J., Fenollar-Ferrer, C., Bashir, R., Bukhari, I., Bouzid, A., Shaukat, U., Azaiez, H., Booth, K.T., Kahrizi, K., Najmabadi, H., Maqsood, A., Wilson, E.A., Fitzgerald, T.S., Tlili, A., Olszewski, R., Lund, M., Chaudhry, T., Rehman, A.U., Starost, M.F., Waryah, A.M., Hoa, M., Dong, L., Morell, R.J., Smith, R.J.H., Riazuddin, S., Masmoudi, S., Kindt, K., Naz, S., Friedman, T.B. (2017) CDC14A Phosphatase is Essential for Hearing and Male Fertility in Mouse and Human. Human molecular genetics. 27(5):780-798
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Delmaghani, S., Aghaie, A., Bouyacoub, Y., El Hachmi, H., Bonnet, C., Riahi, Z., Chardenoux, S., Perfettini, I., Hardelin, J.P., Houmeida, A., Herbomel, P., Petit, C. (2016) Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness. American journal of human genetics. 98:1266-1270
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Clément, A., Solnica-Krezel, L., and Gould, K.L. (2012) Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(12):1911-1921
- Clément, A., Solnica-Krezel, L., and Gould, K.L. (2011) The Cdc14B phosphatase contributes to ciliogenesis in zebrafish. Development (Cambridge, England). 138(2):291-302
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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