Gene
naalad2
- ID
- ZDB-GENE-040426-1025
- Name
- N-acetylated alpha-linked acidic dipeptidase 2
- Symbol
- naalad2 Nomenclature History
- Previous Names
-
- zgc:56429 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable carboxypeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in plasma membrane. Is expressed in epidermis; nervous system; otic vesicle; periderm; and pronephros. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56429 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003137 | PA domain |
| Domain | IPR007365 | Transferrin receptor-like, dimerisation domain |
| Domain | IPR007484 | Peptidase M28 |
| Family | IPR039373 | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
| Homologous_superfamily | IPR036757 | Transferrin receptor-like, dimerisation domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | PA domain | PA domain superfamily | Peptidase M28 | Transferrin receptor-like, dimerisation domain | Transferrin receptor-like, dimerisation domain superfamily | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B1C9
|
449 | ||||||
|
UniProtKB:Q7ZUD9
|
745 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
naalad2-201
(1)
|
Ensembl | 2,395 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-184E5 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-452L20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56429 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200277 (1) | 2431 nt | ||
| Genomic | GenBank:CU694529 (2) | 34865 nt | ||
| Polypeptide | UniProtKB:Q7ZUD9 (1) | 745 aa |
- Cao, Z., Liu, G., Zhang, H., Wang, M., Xu, Y. (2022) Nox4 promotes osteoblast differentiation through TGF-beta signal pathway. Free radical biology & medicine. 193(Pt 2):595-609
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pradhan, A., Asnake, S., Kharlyngdoh, J.B., Modig, C., Olsson, P.E. (2015) In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Chemico-biological interactions. 233:35-45
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 4 of 4
Show