Gene
qars1
- ID
- ZDB-GENE-040426-1011
- Name
- glutaminyl-tRNA synthetase 1
- Symbol
- qars1 Nomenclature History
- Previous Names
-
- qars
- zgc:56395
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have glutamine-tRNA ligase activity. Predicted to be involved in glutaminyl-tRNA aminoacylation. Predicted to localize to aminoacyl-tRNA synthetase multienzyme complex and cytosol. Is expressed in liver. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141420 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microcephaly, progressive, seizures, and cerebral and cerebellar atrophy | 615760 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR007638 | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 |
| Domain | IPR007639 | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal |
| Domain | IPR020058 | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain |
| Family | IPR000924 | Glutamyl/glutaminyl-tRNA synthetase |
| Family | IPR050132 | Glutamine/Glutamate--tRNA Ligase |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR042558 | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 |
| Homologous_superfamily | IPR042559 | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class I, conserved site | Glutamine/Glutamate--tRNA Ligase | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 | Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 | Glutamyl/glutaminyl-tRNA synthetase | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZWG7
|
437 |
Interactions and Pathways
No data available
Plasmids
No data available