Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040420-1
Gene Name: alkaline phosphatase, liver/bone/kidney
Gene Symbol: alpl
Previous Names: alp (1), zgc:56672
Location: Chr: 11   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 16 figures from 9 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [MGC:56672]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
  alar plate midbrain region, cerebellum, epiphysis, forebrain (all 21) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la011993Tg
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Hypophosphatasia, adult 146300
Hypophosphatasia, childhood 241510
Hypophosphatasia, infantile 241500
Odontohypophosphatasia 146300
GENE ONTOLOGY
Ontology GO Term
Biological Process response to mechanical stimulus (more)
Molecular Function alkaline phosphatase activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001952 (1)
  • InterPro:IPR017849 (1)
  • InterPro:IPR017850 (1)
  • InterPro:IPR018299 (1)
  • PROSITE:PS00123 (1)
  • Pfam:PF00245 (1)
  • EC:3.1.3.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA alpl-001 (1) 1871
    alpl-002 (1) 812
    alpl-003 (1) 640
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alpl
    Tg(alpl:mCherry)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    alpl Contained in: [BAC] CH211-220M17 (1) (order this)
    alpl Encodes: [cDNA] MGC:56672 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201007 (1) 1739 bp
    Genomic GenBank:BX248318 (1) 194209 bp
    Select Tool
    Polypeptide UniProtKB:F1Q5B5 (1) 561 aa
    Sequence Clusters UniGene:116988 (1)
    Sequence Information (all 29)
    OTHER alpl GENE PAGES
  • Gene:393982 (1)
  • VEGA:OTTDARG00000020427 (1)
  • Ensembl(Zv9):ENSDARG00000015546 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish alpl 11  
    Human ALPL 1 (1p36.12)
  • OMIM:171760
  • Gene:249
  • Mouse Alpl 4 ( 70.02 cM)
  • MGI:87983
  • Gene:11647
  • Orthology Details
    CITATIONS (31)