Gene

mdh1aa

ID

ZDB-GENE-040204-1

Name

malate dehydrogenase 1Aa, NAD (soluble)

Symbol

mdh1aa Nomenclature History

Previous Names

mdh1a
MDH1b (1)
fj05b08
wu:fj05b08

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have L-malate dehydrogenase activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Predicted to localize to cytosol. Is expressed in several structures, including digestive system; integument; mesoderm; pectoral fin; and sensory system. Orthologous to human MDH1 (malate dehydrogenase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63941 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mdh1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 88	Alliance	?Developmental and epileptic encephalopathy 88	618959

Associated With mdh1aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001252	Malate dehydrogenase, active site
Domain	IPR001236	Lactate/malate dehydrogenase, N-terminal
Domain	IPR022383	Lactate/malate dehydrogenase, C-terminal
Family	IPR001557	L-lactate/malate dehydrogenase
Family	IPR010945	Malate dehydrogenase, type 2
Family	IPR011274	Malate dehydrogenase, NAD-dependent, cytosolic
Homologous_superfamily	IPR015955	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal	Lactate/malate dehydrogenase, C-terminal	Lactate/malate dehydrogenase, N-terminal	L-lactate/malate dehydrogenase	Malate dehydrogenase, active site	Malate dehydrogenase, NAD-dependent, cytosolic	Malate dehydrogenase, type 2	NAD(P)-binding domain superfamily
UniProtKB:Q7T3D9 InterPro	305
UniProtKB:A0A2R9YJL1 InterPro	350
UniProtKB:Q801E6 InterPro	333
UniProtKB:A0A8M1P861 InterPro	354

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mdh1aa-201 (1) Ensembl	Ensembl	1,714 nt	Select Tool ZFIN BLAST
mRNA	mdh1aa-202 (1) Ensembl	Ensembl	1,472 nt	Select Tool
mRNA	mdh1aa-204 (1) Ensembl	Ensembl	507 nt	Select Tool
mRNA	mdh1aa-205 (1) Ensembl	Ensembl	363 nt	Select Tool
mRNA	mdh1aa-206 (1) Ensembl	Ensembl	689 nt	Select Tool
ncRNA	mdh1aa-003 (1) Ensembl	Ensembl	514 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations