Gene
ing3
- ID
- ZDB-GENE-040109-3
- Name
- inhibitor of growth family, member 3
- Symbol
- ing3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Orthologous to human ING3 (inhibitor of growth family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56327 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1532 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6930 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15341 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16070 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18549 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40231 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR024610 | Inhibitor of growth protein, N-terminal histone-binding |
| Domain | IPR042020 | ING3, PHD domain |
| Family | IPR028651 | ING family |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | ING3, PHD domain | ING family | Inhibitor of growth protein, N-terminal histone-binding | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TEM2 | InterPro | 416 | ||||||||
| UniProtKB:A0AB32TL75 | InterPro | 328 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-152M4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-24J9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56327 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200937 (1) | 2139 nt | ||
| Genomic | GenBank:AL929016 (1) | 200582 nt | ||
| Polypeptide | UniProtKB:Q6TEM2 (1) | 416 aa |
- Song, G., Feng, G., Li, Q., Peng, J., Ge, W., Long, Y., Cui, Z. (2024) Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish. International Journal of Molecular Sciences. 25(13):
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- He, G.H., Helbing, C.C., Wagner, M.J., Sensen, C.W., and Riabowol, K. (2005) Phylogenetic Analysis of the ING Family of PHD Finger Proteins. Mol. Biol. Evol.. 22(1):104-116
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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