Gene
dscamb
- ID
- ZDB-GENE-031118-67
- Name
- Down syndrome cell adhesion molecule b
- Symbol
- dscamb Nomenclature History
- Previous Names
-
- fm10g02
- si:ch211-69g13.1 (1)
- wu:fm10g02
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within enteric nervous system development. Predicted to be located in membrane and synapse. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in central nervous system; intestinal bulb; and retina. Orthologous to human DSCAM (DS cell adhesion molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la219 | Allele with one deletion | Unknown | Unknown | TALEN | |
| la220 | Allele with one deletion | Unknown | Unknown | TALEN | |
| la221 | Allele with one delins | Unknown | Unknown | TALEN | |
| la222 | Allele with one deletion | Unknown | Unknown | TALEN | |
| sa2791 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13818 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14192 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22586 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28403 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39033 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dscamb | Julien et al., 2018 | |
| CRISPR2-dscamb | Julien et al., 2018 | |
| MO1-dscamb | N/A | Lu et al., 2021 |
| TALEN1-dscamb | Julien et al., 2018 | |
| TALEN2-dscamb | Julien et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AIA2 | InterPro | 2018 | |||||||||
| UniProtKB:F1Q4W9 | InterPro | 2020 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dscamb-201
(1)
|
Ensembl | 6,063 nt | ||
| mRNA |
dscamb-202
(1)
|
Ensembl | 6,992 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(dscamb:GAL4FF) |
|
| 1 | Julien et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69G13 | ZFIN Curated Data | |
| Encodes | EST | fm10g02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009291474 (1) | 7426 nt | ||
| Genomic | GenBank:CR388412 (2) | 158289 nt | ||
| Polypeptide | UniProtKB:F1Q4W9 (1) | 2020 aa |
- Lu, Y.J., Yu, W.W., Cui, M.M., Yu, X.X., Song, H.L., Bai, M.R., Wu, W.J., Gu, B.L., Wang, J., Cai, W., Chu, X. (2021) Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish. Frontiers in cell and developmental biology. 9:641152
- Galicia, C.A., Sukeena, J.M., Stenkamp, D.L., Fuerst, P.G. (2018) Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina.. Molecular Vision. 24:443-458
- Julien, D.P., Chan, A.W., Barrios, J., Mathiaparanam, J., Douglass, A., Wolman, M.A., Sagasti, A. (2018) Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival. Journal of neurogenetics. 32(4):336-352
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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