Gene
pfkfb4b
- ID
- ZDB-GENE-031031-4
- Name
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
- Symbol
- pfkfb4b Nomenclature History
- Previous Names
-
- pfkfb4
- pfkfb4l
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Is expressed in central nervous system; forerunner cell group; intermediate cell mass of mesoderm; neural plate; and ventral mesoderm. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64150 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025557Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025558Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001345 | Phosphoglycerate/bisphosphoglycerate mutase, active site |
| Domain | IPR013079 | 6-phosphofructo-2-kinase |
| Family | IPR003094 | Fructose-2,6-bisphosphatase |
| Family | IPR013078 | Histidine phosphatase superfamily, clade-1 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Length | 6-phosphofructo-2-kinase | Fructose-2,6-bisphosphatase | Histidine phosphatase superfamily | Histidine phosphatase superfamily, clade-1 | Phosphoglycerate/bisphosphoglycerate mutase, active site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F6NXI0
|
485 | ||||||
|
UniProtKB:Q7T325
|
469 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pfkfb4b-201
(1)
|
Ensembl | 2,684 nt | ||
| mRNA |
pfkfb4b-202
(1)
|
Ensembl | 2,227 nt | ||
| ncRNA |
pfkfb4b-003
(1)
|
Ensembl | 792 nt | ||
| ncRNA |
pfkfb4b-004
(1)
|
Ensembl | 456 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-197J19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64150 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73295 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001430986 (1) | 2713 nt | ||
| Genomic | GenBank:CU467879 (1) | 109354 nt | ||
| Polypeptide | UniProtKB:F6NXI0 (1) | 485 aa |
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Ge, G., Long, Y., Song, G., Li, Q., Cui, Z., Yan, H. (2022) Transcriptomic Profiling Revealed Signaling Pathways Associated with the Spawning of Female Zebrafish under Cold Stress. International Journal of Molecular Sciences. 23(14):
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chatzopoulou, A., Roy, U., Meijer, A.H., Alia, A., Spaink, H.P., Schaaf, M.J. (2015) Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish. Endocrinology. 156(5):1757-69
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, Y., Linsen, S.E. (2015) Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes. BMC Genomics. 16:427
- Ben-Moshe, Z., Alon, S., Mracek, P., Faigenbloom, L., Tovin, A., Vatine, G.D., Eisenberg, E., Foulkes, N.S., and Gothilf, Y. (2014) The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Nucleic acids research. 42(6):3750-67
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
- Ho, N.Y., Yang, L., Legradi, J., Armant, O., Takamiya, M., Rastegar, S., and Strähle, U. (2013) Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury. Environmental science & technology. 47(7):3316-25
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