Gene
egfra
- ID
- ZDB-GENE-030918-1
- Name
- epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
- Symbol
- egfra Nomenclature History
- Previous Names
-
- egfr
- erbb1a (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in blood vessel lumenization. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; colorectal cancer; lung cancer (multiple); pancreatic cancer; and prostate cancer. Is expressed in several structures, including gill; lens; liver; pleuroperitoneal region; and somite. Orthologous to human EGFR (epidermal growth factor receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Adenocarcinoma of lung, response to tyrosine kinase inhibitor in | 211980 |
| lung cancer | Alliance | Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in | 211980 |
| lung cancer | Alliance | {Nonsmall cell lung cancer, susceptibility to} | 211980 |
| Neonatal nephrocutaneous inflammatory syndrome | 616069 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Domain | IPR049328 | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment |
| Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Epidermal growth factor receptor, juxtamembrane domain | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SZF7
|
1191 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
egfra-201
(1)
|
Ensembl | 1,868 nt | ||
| mRNA |
egfra-202
(1)
|
Ensembl | 1,881 nt | ||
| mRNA |
egfra-203
(1)
|
Ensembl | 2,437 nt | ||
| mRNA |
egfra-205
(1)
|
Ensembl | 3,168 nt | ||
| mRNA |
egfra-206
(1)
|
Ensembl | 3,007 nt | ||
| mRNA |
egfra-207
(1)
|
Ensembl | 6,151 nt | ||
| ncRNA |
egfra-006
(1)
|
Ensembl | 518 nt |
Interactions and Pathways
Plasmids
No data available