Gene

cdk8

ID

ZDB-GENE-030903-2

Name

cyclin dependent kinase 8

Symbol

cdk8 Nomenclature History

Previous Names

wu:fk95h11

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147230 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdk8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder with hypotonia and behavioral abnormalities	618748

Associated With cdk8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050108	Cyclin-dependent kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily