Gene
birc2
- ID
- ZDB-GENE-030825-6
- Name
- baculoviral IAP repeat containing 2
- Symbol
- birc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of programmed cell death; positive regulation of protein ubiquitination; and regulation of cell cycle. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in MALT lymphoma; breast cancer; and carcinoma (multiple). Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903716 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR041933 | BIRC2/BIRC3, UBA domain |
| Domain | IPR048875 | BIRC2/3-like, UBA domain |
| Family | IPR050784 | Inhibitor of Apoptosis |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Repeat | IPR001370 | BIR repeat |
Domain Details Per Protein
| Protein | Length | BIRC2/3-like, UBA domain | BIRC2/BIRC3, UBA domain | BIR repeat | CARD domain | Death-like domain superfamily | Inhibitor of Apoptosis | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QDZ3
|
633 | ||||||||
|
UniProtKB:Q7T0K2
|
647 | ||||||||
|
UniProtKB:Q8UWD2
|
628 |
Interactions and Pathways
No data available
Plasmids
No data available