Gene
casp2
- ID
- ZDB-GENE-030825-3
- Name
- caspase 2, apoptosis-related cysteine peptidase
- Symbol
- casp2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity involved in apoptotic process. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of apoptotic process; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to cytoplasm. Is expressed in digestive system; nervous system; and pharyngeal arch. Orthologous to human CASP2 (caspase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Spead et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly | 620653 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR001315 | CARD domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
| Domain | IPR035702 | Caspase-2, CARD domain |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | CARD domain | Caspase-2, CARD domain | Caspase-like domain superfamily | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A288CG41
|
437 | ||||||||||
|
UniProtKB:Q0PKX3
|
435 | ||||||||||
|
UniProtKB:A0A8M9P7T2
|
313 |
Interactions and Pathways
No data available
Plasmids
No data available