Gene
tph1b
- ID
- ZDB-GENE-030805-6
- Name
- tryptophan hydroxylase 1b
- Symbol
- tph1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in axial mesoderm; axis; epiphysis; margin; and raphe nucleus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and nicotine dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6906768 (3 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tph1b | (2) | |
| CRISPR2-tph1b | (2) | |
| MO1-tph1b | N/A | Kwan et al., 2016 |
| MO2-tph1b | N/A | Pan et al., 2020 |
| TALEN1-tph1b | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR002912 | ACT domain |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041904 | Tryptophan 5-hydroxylase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
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Domain Details Per Protein
| Protein | Length | ACT domain | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tryptophan 5-hydroxylase, catalytic domain | Tryptophan 5-monooxygenase | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A2VCX5
|
480 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(tph1b:Cre-ERT2,cryaa:EGFP) |
|
| 1 | (4) | |
| Tg(tph1b:EGFP) |
|
| 1 | (3) | |
| Tg(tph1b:mCherry,myl7:EGFP) |
|
| 1 | (4) | |
| Tg(tph1b:mCherry-NTR) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194P6 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6906768 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158168 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173437 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001843 (1) | 2155 nt | ||
| Genomic | GenBank:BX284688 (1) | 236784 nt | ||
| Polypeptide | UniProtKB:A2VCX5 (1) | 480 aa |
- Miyazaki, S., Shimizu, N., Miyahara, H., Teranishi, H., Umeda, R., Yano, S., Shimada, T., Shiraishi, H., Komiya, K., Katoh, A., Yoshimura, A., Hanada, R., Hanada, T. (2024) DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and Biophysical Research Communications. 712-713:149932149932
- Tea, M., Pan, Y.K., Lister, J.G.R., Perry, S.F., Gilmour, K.M. (2024) Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 210(5):785-799
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Ichikawa, S., Abe, R., Fujimoto, H., Higashi, K., Zang, L., Nakayama, H., Matsuoka, I., Shimada, Y. (2023) Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism. Frontiers in microbiology. 14:10791871079187
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Horzmann, K.A., Lin, L.F., Taslakjian, B., Yuan, C., Freeman, J.L. (2022) Anxiety-related behavior and associated brain transcriptome and epigenome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Chemosphere. 308(Pt 3):136431
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Kawabe, M., Nishida, T., Horita, C., Ikeda, A., Takahashi, R., Inui, A., Shiozaki, K. (2022) Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish. Frontiers in pharmacology. 13:905711
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
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