Gene
sult1st2
- ID
- ZDB-GENE-030804-27
- Name
- sulfotransferase family 1, cytosolic sulfotransferase 2
- Symbol
- sult1st2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables estrone sulfotransferase activity. Involved in xenobiotic metabolic process. Acts upstream of or within estrogen metabolic process. Predicted to be active in cytoplasm. Is expressed in intestinal bulb. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56249 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|
|
UniProtKB:Q7ZUS4
|
301 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sult1st2-201
(1)
|
Ensembl | 1,622 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196G2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56249 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_183347 (1) | 1931 nt | ||
| Genomic | GenBank:AL935148 (1) | 195396 nt | ||
| Polypeptide | UniProtKB:Q7ZUS4 (1) | 301 aa |
No data available
- Li, H., Zhao, F., Cao, F., Teng, M., Yang, Y., Qiu, L. (2019) Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 251:203-211
- Yamauchi, K., Katsumata, S., Ozaki, M. (2019) A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Genes & genetic systems. 94(5):207-217
- Zhou, S., Wei, Z., Chu, T., Yu, H., Li, S., Zhang, W., Gui, W. (2018) Transcriptomic analysis of zebrafish (Danio rerio) embryos to assess integrated biotoxicity of Xitiaoxi River waters. Environmental pollution (Barking, Essex : 1987). 242:42-53
- Yang, J., Zhao, H., Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99-induced cyp1a mRNA in zebrafish larvae.. Toxicology reports. 4:614-624
- Zhou, Z., Yang, J., Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 191:175-188
- Xi, Y., Seyoum, H., Liu, M.C. (2016) Role of SULT-mediated sulfation in the biotransformation of 2-butoxyethanol and sorbitan monolaurate: A study using zebrafish SULTs. Aquatic toxicology (Amsterdam, Netherlands). 177:19-21
- Yang, J., Chan, K.M. (2015) Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 159C:138-147
- Mohammed, Y.I., Kurogi, K., Shaban, A.A., Xu, Z., Liu, M.Y., Williams, F.E., Sakakibara, Y., Suiko, M., Bhuiyan, S., and Liu, M.C. (2012) Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5. Aquatic toxicology (Amsterdam, Netherlands). 112-113C:11-18
- Li, Z.H., Alex, D., Siu, S.O., Chu, I.K., Renn, J., Winkler, C., Lou, S., Tsui, S.K., Zhao, H.Y., Yan, W.R., Mahady, G.B., Li, G.H., Kwan, Y.W., Wang, Y.T., and Lee, S.M. (2011) Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Molecular Biosystems. 7(7):2128-38
- Kurogi, K., Dillon, J., Nasser, A., Liu, M.Y., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.C. (2010) Sulfation of Drug Compounds by the Zebrafish Cytosolic Sulfotransferases (SULTs). Drug metabolism letters. 4(2):62-68
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