Gene

lamp2

ID

ZDB-GENE-030729-9

Name

lysosomal-associated membrane protein 2

Symbol

lamp2 Nomenclature History

Previous Names

sb:cb587
wu:fb14a06
zgc:103532

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to be involved in autophagosome maturation; cellular response to starvation; and protein targeting to lysosome involved in chaperone-mediated autophagy. Predicted to localize to bounding membrane of organelle and plasma membrane. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Is expressed in cardiovascular system; heart; solid lens vesicle; vein; and yolk syncytial layer. Orthologous to human LAMP2 (lysosomal associated membrane protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb587 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Dvornikov et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lamp2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Danon disease	Alliance	Danon disease	300257

Associated With lamp2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Danon disease	lamp2^xu082/xu082 (WIK)	standard conditions	Dvornikov et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR048524	Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
Domain	IPR048528	Lysosome-associated membrane glycoprotein 2-like, luminal domains
Family	IPR002000	Lysosome-associated membrane glycoprotein

Domain Details Per Protein

Protein	Length	Lysosome-associated membrane glycoprotein	Lysosome-associated membrane glycoprotein 2-like, luminal domains	Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
UniProtKB:Q5BKX3 InterPro	355
UniProtKB:A0A2R8Q0I4 InterPro	358
UniProtKB:A0A0R4IZ00 InterPro	356

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lamp2-201 (1) Ensembl	Ensembl	2,432 nt	Select Tool
mRNA	lamp2-202 (1) Ensembl	Ensembl	786 nt	Select Tool
mRNA	lamp2-204 (1) Ensembl	Ensembl	826 nt	Select Tool
mRNA	lamp2-206 (1) Ensembl	Ensembl	893 nt	Select Tool
mRNA	lamp2-207 (1) Ensembl	Ensembl	1,245 nt	Select Tool ZFIN BLAST
mRNA	lamp2-208 (1) Ensembl	Ensembl	1,242 nt	Select Tool ZFIN BLAST
mRNA	lamp2-209 (1) Ensembl	Ensembl	1,251 nt	Select Tool ZFIN BLAST
mRNA	lamp2-210 (1) Ensembl	Ensembl	1,263 nt	Select Tool ZFIN BLAST
ncRNA	lamp2-003 (1) Ensembl	Ensembl	432 nt	Select Tool
ncRNA	lamp2-006 (1) Ensembl	Ensembl	593 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations