Gene
nfe2l2a
- ID
- ZDB-GENE-030723-2
- Name
- nfe2 like bZIP transcription factor 2a
- Symbol
- nfe2l2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits protein heterodimerization activity and transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including cellular response to oxidative stress; cellular response to prostaglandin stimulus; and positive regulation of transcription, DNA-templated. Localizes to cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and sensory system. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency, developmental delay, and hypohomocysteinemia | 617744 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004826 | Basic leucine zipper domain, Maf-type |
| Domain | IPR004827 | Basic-leucine zipper domain |
| Family | IPR047167 | Nuclear Factor Erythroid-derived 2-like |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
Domain Details Per Protein
| Protein | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Basic-leucine zipper domain superfamily | Nuclear Factor Erythroid-derived 2-like | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q8JIM1
|
586 | |||||
|
UniProtKB:A0A8M2BJQ0
|
585 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfe2l2a-201
(1)
|
Ensembl | 4,739 nt |
Interactions and Pathways
No data available
Plasmids
No data available