Gene

pms1

ID

ZDB-GENE-030616-528

Name

PMS1 homolog 1, mismatch repair system component

Symbol

pms1 Nomenclature History

Previous Names

si:dz164h20.2
si:dz72b14.2

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have ATPase activity. Predicted to be involved in mismatch repair. Predicted to localize to MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; dermatomyositis; and pancreatic ductal carcinoma. Orthologous to human PMS1 (PMS1 homolog 1, mismatch repair system component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66424 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pms1 Human Ortholog

No data available

Associated With pms1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR014762	DNA mismatch repair, conserved site
Domain	IPR009071	High mobility group box domain
Domain	IPR013507	DNA mismatch repair protein, S5 domain 2-like
Family	IPR002099	DNA mismatch repair protein MutL/Mlh/PMS
Family	IPR038973	DNA mismatch repair protein MutL/Mlh/Pms-like
Homologous_superfamily	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR036890	Histidine kinase/HSP90-like ATPase superfamily
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	DNA mismatch repair, conserved site	DNA mismatch repair protein MutL/Mlh/PMS	DNA mismatch repair protein MutL/Mlh/Pms-like	DNA mismatch repair protein, S5 domain 2-like	High mobility group box domain	High mobility group box domain superfamily	Histidine kinase/HSP90-like ATPase superfamily	Ribosomal protein uS5 domain 2-type superfamily	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
UniProtKB:Q8JFR9 InterPro	896

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ottdart00000001858 (1)	Havana	117 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000003997 (1)	Havana	659 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pms1-201 (1) Ensembl	Ensembl	2,929 nt	Select Tool ZFIN BLAST
mRNA	pms1-202 (1) Ensembl	Ensembl	2,862 nt	Select Tool ZFIN BLAST
mRNA	pms1-203 (1) Ensembl	Ensembl	2,649 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations