Gene

mhc2dga

ID

ZDB-GENE-030616-505

Name

major histocompatibility complex class II DGA gene

Symbol

mhc2dga Nomenclature History

Previous Names

mhc2d8.35a2
si:busm1-194e12.11 (1)
si:busm1-48c11.3
si:dz194e12.11
si:dz48c11.3

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including HLA-DOA (major histocompatibility complex, class II, DO alpha); HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1); and HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2).

Genome Resources

Note

novel protein similar to MHC class II alpha chain novel MHCII alpha chain protein

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:113851 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mhc2dga Human Ortholog

No data available

Associated With mhc2dga Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
Domain	IPR001003	MHC class II, alpha chain, N-terminal
Domain	IPR003597	Immunoglobulin C1-set
Domain	IPR007110	Immunoglobulin-like domain
Family	IPR050160	Major Histocompatibility Complex/Immunoglobulin
Homologous_superfamily	IPR011162	MHC classes I/II-like antigen recognition protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014745	MHC class II, alpha/beta chain, N-terminal
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin C1-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin/major histocompatibility complex, conserved site	Major Histocompatibility Complex/Immunoglobulin	MHC classes I/II-like antigen recognition protein	MHC class II, alpha/beta chain, N-terminal	MHC class II, alpha chain, N-terminal
UniProtKB:Q8WM94 InterPro	236

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mhc2dga-201 (1) Ensembl	Ensembl	928 nt	Select Tool ZFIN BLAST
mRNA	si:busm1-48c11.3-001 (1)	Havana	755 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	si:busm1-194e12.11-001 (1)	Havana	718 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations