Gene
triob
- ID
- ZDB-GENE-030616-399
- Name
- trio Rho guanine nucleotide exchange factor b
- Symbol
- triob Nomenclature History
- Previous Names
-
- trio
- si:dz230d15.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; Rho guanyl-nucleotide exchange factor activity; and protein kinase activity. Predicted to be involved in axon guidance; central nervous system development; and protein phosphorylation. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1114 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant intellectual developmental disorder 44 | Alliance | Intellectual developmental disorder, autosomal dominant 44, with microcephaly | 617061 |
Intellectual developmental disorder, autosomal dominant 63, with macrocephaly | 618825 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000219 | Dbl homology (DH) domain |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001251 | CRAL-TRIO lipid binding domain |
Domain | IPR001452 | SH3 domain |
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR003598 | Immunoglobulin subtype 2 |
Domain | IPR003599 | Immunoglobulin subtype |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013098 | Immunoglobulin I-set |
Domain | IPR028570 | Kalirin/Triple functional domain protein, SH3 domain 1 |
Domain | IPR047053 | Kalirin/Triple functional domain protein, SH3 domain 2 |
Domain | IPR047054 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
Repeat | IPR002017 | Spectrin repeat |
Repeat | IPR018159 | Spectrin/alpha-actinin |
Domain Details Per Protein
Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 | Kalirin/Triple functional domain protein, SH3 domain 1 | Kalirin/Triple functional domain protein, SH3 domain 2 | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | SH3 domain | SH3-like domain superfamily | Spectrin/alpha-actinin | Spectrin repeat |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3AHT8
|
3023 |
- Genome Browsers
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA | ottdart00000001996 (1) | Havana | 2271 nt |
Interactions and Pathways
No data available
Plasmids
No data available