Gene

stat1b

ID

ZDB-GENE-030616-23

Name

signal transducer and activator of transcription 1b

Symbol

stat1b Nomenclature History

Previous Names

si:by134g18.3
si:by51f19.2
si:dz199m19.2
si:dz73o4.3
si:dz87i4.1
si:xx-51f19.2
wu:fi49f02

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hemopoiesis. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; primary immunodeficiency disease; and prostate adenocarcinoma. Is expressed in cardiovascular system; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Orthologous to human STAT1 (signal transducer and activator of transcription 1).

Genome Resources

Note

novel protein similar to human signal transduction and activator of transcription 1 (STAT1)

Comparative Information

Expression

All Expression Data

21 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Song et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stat1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chronic mucocutaneous candidiasis	Alliance	Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant	614162
immunodeficiency 31A	Alliance	Immunodeficiency 31A, mycobacteriosis, autosomal dominant	614892
immunodeficiency 31B	Alliance	Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive	613796
immunodeficiency 31C	Alliance	Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant	614162

Associated With stat1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR013799	STAT transcription factor, protein interaction
Domain	IPR013800	STAT transcription factor, all-alpha domain
Domain	IPR013801	STAT transcription factor, DNA-binding
Domain	IPR048988	Signal transducer and activator of transcription, linker domain
Family	IPR001217	Transcription factor STAT
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012345	STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily	IPR015988	STAT transcription factor, coiled coil
Homologous_superfamily	IPR036535	STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	p53-like transcription factor, DNA-binding domain superfamily	SH2 domain	SH2 domain superfamily	Signal transducer and activator of transcription, linker domain	STAT transcription factor, all-alpha domain	STAT transcription factor, coiled coil	STAT transcription factor, DNA-binding	STAT transcription factor, DNA-binding, N-terminal	STAT transcription factor, N-terminal domain superfamily	STAT transcription factor, protein interaction	Transcription factor STAT
UniProtKB:A0A8M3B5U5 InterPro	708
UniProtKB:A0A8M9QF99 InterPro	634
UniProtKB:A0A8M9PRY3 InterPro	609
UniProtKB:A0A8M9Q4I2 InterPro	438
UniProtKB:A0A8M9QAL7 InterPro	683
UniProtKB:A0A8M9QJJ2 InterPro	640
UniProtKB:B0S789 InterPro	725

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ottdart00000001761 (1)	Havana	682 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000001848 (1)	Havana	1,706 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000056007 (1)	Havana	1,527 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	stat1b-201 (1) Ensembl	Ensembl	4,113 nt	Select Tool ZFIN BLAST
mRNA	stat1b-202 (1) Ensembl	Ensembl	535 nt	Select Tool
mRNA	stat1b-204 (1) Ensembl	Ensembl	3,189 nt	Select Tool
ncRNA	stat1b-003 (1) Ensembl	Ensembl	363 nt	Select Tool
ncRNA	stat1b-004 (1) Ensembl	Ensembl	812 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations