Gene
itsn1
- ID
- ZDB-GENE-030616-226
- Name
- intersectin 1 (SH3 domain protein)
- Symbol
- itsn1 Nomenclature History
- Previous Names
-
- si:dz173a8.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis. Predicted to act upstream of or within endocytosis and intracellular signal transduction. Predicted to be located in cell projection and synapse. Predicted to be active in cytoplasm; intracellular vesicle; and presynaptic membrane. Is expressed in head. Orthologous to human ITSN1 (intersectin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Dergai et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000261 | EH domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR032140 | Intersectin-1, AP2 binding region |
| Family | IPR051480 | Endocytic & GEF Adapter |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | EH domain | Endocytic & GEF Adapter | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | Intersectin-1, AP2 binding region | PH-like domain superfamily | Pleckstrin homology domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BIA8
|
1250 | |||||||||||||||
|
UniProtKB:Q8JFT4
|
1721 | |||||||||||||||
|
UniProtKB:A0A8M2BI58
|
1746 | |||||||||||||||
|
UniProtKB:A0A8M2BIP7
|
1751 |
Interactions and Pathways
No data available
Plasmids
No data available