Gene

col5a2a

ID

ZDB-GENE-030616-13

Name

collagen, type V, alpha 2a

Symbol

col5a2a Nomenclature History

Previous Names

col5a2l
im:7038599
si:by143e18.1
si:ch211-198b21.5
si:dz167c3.3
wu:fa13f03
wu:fa98d01
wu:fj05e03

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be part of collagen type V trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including epidermis; median fin fold; paraxial mesoderm; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome classic type 2. Orthologous to human COL5A2 (collagen type V alpha 2 chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7146646 (1 image)
eu144 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With col5a2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ehlers-Danlos syndrome classic type 2	Alliance	Ehlers-Danlos syndrome, classic type, 2	130010

Associated With col5a2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000885	Fibrillar collagen, C-terminal
Domain	IPR001007	VWFC domain
Family	IPR050149	Collagen superfamily
Repeat	IPR008160	Collagen triple helix repeat

Domain Details Per Protein

Protein	Length	Collagen superfamily	Collagen triple helix repeat	Fibrillar collagen, C-terminal	VWFC domain
UniProtKB:A0A8M1NTE7 InterPro	1491

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	col5a2a-001 (1)	Havana	4,276 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	col5a2a-201 (1) Ensembl	Ensembl	5,063 nt	Select Tool ZFIN BLAST
ncRNA	col5a2a-002 (1)	Havana	984 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations