Gene
tshba
- ID
- ZDB-GENE-030513-3
- Name
- thyroid stimulating hormone subunit beta a
- Symbol
- tshba Nomenclature History
- Previous Names
-
- tshb (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within development of secondary sexual characteristics and regulation of thyroid hormone generation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in adenohypophyseal placode; head; hypophysis; and thyroid follicle. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Song et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| TALEN1-tshba | (2) | |
| TALEN2-tshba | Ji et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 4 | Alliance | Hypothyroidism, congenital, nongoitrous 4 | 275100 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Glycoprotein hormone subunit beta | Gonadotropin, beta subunit | Gonadotropin, beta subunit, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PZI4 | InterPro | 129 | ||||
| UniProtKB:Q801K4 | InterPro | 148 | ||||
| UniProtKB:A0A8M9PLW7 | InterPro | 182 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.5tshb:EGFP) |
|
| 1 | (3) | |
| Tg(hsp70l:tshba,myl7:EGFP) |
|
| 1 | Ji et al., 2023 | |
| Tg(tshb:EGFP) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-105J21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193962 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193992 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181494 (1) | 816 nt | ||
| Genomic | GenBank:BX950174 (1) | 170278 nt | ||
| Polypeptide | UniProtKB:A0A8M9PLW7 (1) | 182 aa |
- Fang, Y., Wan, J.P., Wang, Z., Song, S.Y., Zhang, C.X., Yang, L., Zhang, Q.Y., Yan, C.Y., Wu, F.Y., Lu, S.Y., Sun, F., Han, B., Zhao, S.X., Dong, M., Song, H.D. (2024) Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. Nature communications. 15:31653165
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Roisman-Geller, N., Pisanty, O., Weinberger, A., Gajbhiye, D.S., Golan, M., Gothilf, Y. (2024) Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish. International Journal of Molecular Sciences. 25(13):
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zhang, C., Yang, L., Zhang, H., Wu, F., Zhang, Y., Zhang, K., Wu, C., Li, R., Dong, M., Zhao, S., Song, H. (2024) TAF1 is needed for the proliferation and maturation of thyroid follicle cells via Notch signaling. American journal of physiology. Endocrinology and metabolism. 326(6):E832-E841
- Ji, C., Ou, Y., Yu, W., Lv, J., Zhang, F., Li, H., Gu, Z., Li, J., Zhong, Z., Wang, H. (2023) Thyroid-stimulating hormone (TSH)-thyroid hormone (TH) signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(1):61-74
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973
- Yan, C.Y., Wu, F.Y., Sun, F., Fang, Y., Zhang, R.J., Zhang, C.R., Zhang, C.X., Wang, Z., Yang, R.M., Yang, L., Dong, M., Zhang, Q.Y., Ye, X.P., Song, H.D., Zhao, S.X. (2023) The isl2a transcription factor regulates pituitary development in zebrafish. Frontiers in endocrinology. 14:920548920548
- Yang, L., Tu, P.H., Zhang, C.X., Xie, R.R., Dong, M., Jing, Y., Chen, X., Wei, G., Song, H.D. (2023) Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae. Frontiers in endocrinology. 14:12046781204678
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