Gene

tshba

ID

ZDB-GENE-030513-3

Name

thyroid stimulating hormone subunit beta a

Symbol

tshba Nomenclature History

Previous Names

tshb (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to contribute to hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to localize to cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Is expressed in adenohypophyseal placode; head; and hypophysis. Orthologous to human TSHB (thyroid stimulating hormone subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

46 figures from 33 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from Song et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tshba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nongoitrous hypothyroidism 4	Alliance	Hypothyroidism, congenital, nongoitrous 4	275100

Associated With tshba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018245	Gonadotropin, beta subunit, conserved site
Domain	IPR006208	Glycoprotein hormone subunit beta
Family	IPR001545	Gonadotropin, beta subunit
Homologous_superfamily	IPR029034	Cystine-knot cytokine