Gene
rps6ka3a
- ID
- ZDB-GENE-030219-119
- Name
- ribosomal protein S6 kinase a, polypeptide 3a
- Symbol
- rps6ka3a Nomenclature History
- Previous Names
-
- rps6ka3
- id:ibd1103
- si:ch211-114c12.12
- wu:fk86e02
- zgc:56006
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ribosomal protein S6 kinase activity. Involved in digestive tract development and skin development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability. Is expressed in several structures, including epidermis; lateral mesoderm; otic vesicle; periderm; and pronephric duct. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56006 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Makky et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Coffin-Lowry syndrome | Alliance | Coffin-Lowry syndrome | 303600 |
| non-syndromic X-linked intellectual disability 19 | Alliance | Intellectual developmental disorder, X-linked 19 | 300844 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR041905 | Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain |
| Domain | IPR041906 | Ribosomal S6 kinase, N-terminal catalytic domain |
| Family | IPR016239 | Ribosomal protein S6 kinase II |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain | Ribosomal protein S6 kinase II | Ribosomal S6 kinase, N-terminal catalytic domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4ID09
|
733 | |||||||||
|
UniProtKB:Q7ZVH8
|
732 | |||||||||
|
UniProtKB:A0A8M9Q888
|
644 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rps6ka3a-201
(1)
|
Ensembl | 3,693 nt |
Interactions and Pathways
No data available
Plasmids
No data available