Gene

mbnl2

ID

ZDB-GENE-030131-9582

Name

muscleblind-like splicing regulator 2

Symbol

mbnl2 Nomenclature History

Previous Names

fj89c04
wu:fj89c04

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Involved in animal organ development; chordate embryonic development; and muscle fiber development. Predicted to localize to cytoplasm and nucleoplasm. Used to study myotonic disease. Is expressed in several structures, including chordo neural hinge; gonad; nervous system; pectoral fin bud; and solid lens vesicle. Orthologous to human MBNL2 (muscleblind like splicing regulator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mbnl2 Human Ortholog

No data available

Associated With mbnl2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myotonic disease	WT + MO2-mbnl2	standard conditions	Machuca-Tzili et al., 2011
myotonic disease	WT + MO3-mbnl2	standard conditions	Machuca-Tzili et al., 2011
myotonic disease	mbnl2^b1360/b1360	standard conditions	Hinman et al., 2021
myotonic disease	WT + MO4-mbnl2	standard conditions	Machuca-Tzili et al., 2011
myotonic disease	WT + MO1-mbnl2	standard conditions	Machuca-Tzili et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000571	Zinc finger, CCCH-type
Domain	IPR041367	E3 ligase, CCCH-type zinc finger
Domain	IPR054429	Muscleblind-like, CCCH zinc finger

Domain Details Per Protein

Protein	Length	E3 ligase, CCCH-type zinc finger	Muscleblind-like, CCCH zinc finger	Zinc finger, CCCH-type
UniProtKB:F1Q5U6 InterPro	208
UniProtKB:B8JIV1 InterPro	371
UniProtKB:A0A8M2BFL2 InterPro	388
UniProtKB:A0A8M9PUY2 InterPro	351
UniProtKB:A0A8M3AWR8 InterPro	383
UniProtKB:A0A8M3B692 InterPro	365
UniProtKB:A0A8M9Q0X5 InterPro	369
UniProtKB:A5YC70 InterPro	339
UniProtKB:B7ZUV4 InterPro	357
UniProtKB:A0A8M3BD13 InterPro	370
UniProtKB:A0A2R8QF26 InterPro	190
UniProtKB:A0A8M3B3A3 InterPro	376
UniProtKB:A0A8M3BD19 InterPro	353

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mbnl2-201 (1) Ensembl	Ensembl	1,630 nt	Select Tool
mRNA	mbnl2-202 (1) Ensembl	Ensembl	1,400 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-203 (1) Ensembl	Ensembl	1,237 nt	Select Tool
mRNA	mbnl2-204 (1) Ensembl	Ensembl	4,028 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-205 (1) Ensembl	Ensembl	5,065 nt	Select Tool
mRNA	mbnl2-206 (1) Ensembl	Ensembl	919 nt	Select Tool
mRNA	mbnl2-207 (1) Ensembl	Ensembl	734 nt	Select Tool
mRNA	mbnl2-208 (1) Ensembl	Ensembl	715 nt	Select Tool
mRNA	mbnl2-210 (1) Ensembl	Ensembl	643 nt	Select Tool
mRNA	mbnl2-211 (1) Ensembl	Ensembl	3,932 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-212 (1) Ensembl	Ensembl	3,539 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-213 (1) Ensembl	Ensembl	1,175 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-214 (1) Ensembl	Ensembl	3,485 nt	Select Tool ZFIN BLAST
ncRNA	mbnl2-003 (1) Ensembl	Ensembl	720 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations