Gene
coro1a
- ID
- ZDB-GENE-030131-9512
- Name
- coronin, actin binding protein, 1A
- Symbol
- coro1a Nomenclature History
- Previous Names
-
- fj83g12
- wu:fj83g12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within brain development; central nervous system projection neuron axonogenesis; and eye development. Predicted to be located in cytoplasm. Is expressed in several structures, including ball; endothelial cell; hematopoietic cell; hematopoietic system; and thymus. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to human CORO1A (coronin 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63766 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Blaker-Lee et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015166Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-coro1a | N/A | (2) |
| MO2-coro1a | N/A | (3) |
| MO3-coro1a | N/A | Bowes et al., 2019 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| coronin-1A deficiency | Alliance | Immunodeficiency 8 | 615401 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR015048 | Domain of unknown function DUF1899 |
| Family | IPR015505 | Coronin |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Coronin | Domain of unknown function DUF1899 | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SX58
|
455 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
coro1a-201
(1)
|
Ensembl | 1,813 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(coro1a:Kaede) |
|
| 1 | (6) | |
| Tg(coro1a:ccr9a,cryaa:Cerulean) |
|
| 1 | Huang et al., 2019 | |
| Tg(coro1a:Dendra2-NTR) |
|
| 1 | Zou et al., 2022 | |
| Tg(coro1a:DsRed) |
|
| 1 | (5) | |
| Tg(coro1a:DsRedx) |
|
| 1 | (9) | |
| Tg(coro1a:EGFP) |
|
| 2 | (71) | |
| Tg(coro1a:GCaMP5) |
|
| 1 | Du et al., 2022 | |
| Tg(coro1a:HA-ikzf1,cryaa:Cerulean) |
|
| 1 | Huang et al., 2019 | |
| Tg(coro1a:Hsa.PAK1-Hsa.KRAS) |
|
| 1 | Liu et al., 2016 | |
| Tg(coro1a:irf4a,cryaa:Cerulean) |
|
| 1 | Huang et al., 2019 |
1 - 10 of 17
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-71F10 | ZFIN Curated Data | |
| Encodes | EST | fj83g12 | ||
| Encodes | cDNA | MGC:63766 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175070 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198116 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198120 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201114 (1) | 1766 nt | ||
| Genomic | GenBank:BX682556 (1) | 244555 nt | ||
| Polypeptide | UniProtKB:Q7SX58 (1) | 455 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Li, K., Fan, D., Zhou, J., Zhao, Z., Han, A., Song, Z., Tang, X., Hu, B. (2024) Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. International Journal of Molecular Sciences. 25(20):
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Zhao, L., Wang, L.F., Wang, Y.C., Liu, A., Xiao, Q.W., Hu, M.C., Sun, M.Z., Hao, H.Y., Gao, Q., Zhao, X., Chen, D.Y. (2024) Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish. Cell biology and toxicology. 40:3636
- Sun, L., Yang, B., Peng, Z., Yang, T., Qin, B., Ao, J., Yang, Y., Wang, J., Zheng, L., Xie, H. (2023) Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Xiao, C., Hou, J., Wang, F., Song, Y., Zheng, J., Luo, L., Wang, J., Ding, W., Zhu, X., Xiong, J.W. (2023) Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration. NPJ Regenerative medicine. 8:2121
- Du, T., Zhou, X., Zhang, R.D.Y., Du, X.F. (2022) Roles of Ca2+ activity in injury-induced migration of microglia in zebrafish in vivo. Biochemistry and biophysics reports. 32:101340
- Lou, L., Yu, T., Dai, Y., Zhao, S., Feng, S., Xu, J., Wen, Z. (2022) Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 119:e2203273119
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Zou, D., Qin, J., Hu, W., Wei, Z., Zhan, Y., He, Y., Zhao, C., Li, L. (2022) Macrophages Rapidly Seal off the Punctured Zebrafish Larval Brain through a Vital Honeycomb Network Structure. International Journal of Molecular Sciences. 23(18)
1 - 10 of 48
Show