Gene
plcd1b
- ID
- ZDB-GENE-030131-9435
- Name
- phospholipase C, delta 1b
- Symbol
- plcd1b Nomenclature History
- Previous Names
-
- DrPLC-delta 1B
- fj78d10
- wu:fj78d10
- zgc:55868
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Is expressed in lens; neuromast; and solid lens vesicle. Orthologous to human PLCD1 (phospholipase C delta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu915 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonsyndromic congenital nail disorder 3 | Alliance | Nail disorder, nonsyndromic congenital, 3, (leukonychia) | 151600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
| Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR015359 | Phosphoinositide-specific phospholipase C, EF-hand-like domain |
| Domain | IPR046975 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain |
| Family | IPR001192 | Phosphoinositide phospholipase C family |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain | C2 domain | C2 domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phosphoinositide-specific phospholipase C, EF-hand-like domain | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BAJ8
|
772 | ||||||||||||
|
UniProtKB:Q7ZU40
|
749 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plcd1b-201
(1)
|
Ensembl | 3,042 nt |
Interactions and Pathways
No data available
Plasmids
No data available