Gene
ncln
- ID
- ZDB-GENE-030131-8788
- Name
- nicalin
- Symbol
- ncln Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable ribosome binding activity. Involved in determination of left/right asymmetry in lateral mesoderm and negative regulation of nodal signaling pathway. Acts upstream of or within enteric nervous system development and regulation of signal transduction. Located in endoplasmic reticulum membrane. Is expressed in central nervous system and intestine. Orthologous to human NCLN (nicalin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65783 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gui et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ncln | Gui et al., 2017 | |
| MO1-ncln | N/A | Gui et al., 2017 |
| MO2-ncln | N/A | Gui et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nicalin | Peptidase M28 |
|---|---|---|---|
|
UniProtKB:Q6NZ07
|
572 | ||
|
UniProtKB:A0A8M2B8R6
|
556 | ||
|
UniProtKB:A0A8M2B8L1
|
557 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-49M19 | ZFIN Curated Data | |
| Encodes | EST | fb07e09 | ||
| Encodes | EST | fk52a06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65783 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77236 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207057 (1) | 2575 nt | ||
| Genomic | GenBank:BX649252 (2) | 205949 nt | ||
| Polypeptide | UniProtKB:Q6NZ07 (1) | 572 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gui, H., Schriemer, D., Cheng, W.W., Chauhan, R.K., Antiňolo, G., Berrios, C., Bleda, M., Brooks, A.S., Brouwer, R.W., Burns, A.J., Cherny, S.S., Dopazo, J., Eggen, B.J., Griseri, P., Jalloh, B., Le, T.L., Lui, V.C., Luzón-Toro, B., Matera, I., Ngan, E.S., Pelet, A., Ruiz-Ferrer, M., Sham, P.C., Shepherd, I.T., So, M.T., Sribudiani, Y., Tang, C.S., van den Hout, M.C., van der Linde, H.C., van Ham, T.J., van IJcken, W.F., Verheij, J.B., Amiel, J., Borrego, S., Ceccherini, I., Chakravarti, A., Lyonnet, S., Tam, P.K., Garcia-Barceló, M.M., Hofstra, R.M. (2017) Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome biology. 18:48
- Sullivan, C., Lage, C.R., Yoder, J.A., Postlethwait, J.H., Kim, C.H. (2017) Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS One. 12:e0179517
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lim, A., Moussavi Nik, S.H., Ebrahimie, E., Lardelli, M. (2015) Analysis of nicastrin gene phylogeny and expression in zebrafish. Development genes and evolution. 225(3):171-8
- Lam, S.H., Hlaing, M.M., Zhang, X., Yan, C., Duan, Z., Zhu, L., Ung, C.Y., Mathavan, S., Ong, C.N., and Gong, Z. (2011) Toxicogenomic and phenotypic analyses of bisphenol-a early-life exposure toxicity in zebrafish. PLoS One. 6(12):e28273
- Dettmer, U., Kuhn, P.H., Abou-Ajram, C., Lichtenthaler, S.F., Krueger, M., Kremmer, E., Haass, C., and Haffner, C. (2010) Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex. The Journal of biological chemistry. 285(34):26174-26181
- Haffner, C., and Haass, C. (2006) Cellular Functions of gamma-Secretase-Related Proteins. Neuro-degenerative Diseases. 3(4-5):284-289
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Haffner, C., and Haass, C. (2004) The Biochemical and Genetic Odyssey to the Function of a Nicastrin-Like Protein. Neuro-degenerative Diseases. 1(4-5):192-195
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