Gene

psmc1a

ID

ZDB-GENE-030131-8730

Name

proteasome 26S subunit, ATPase 1a

Symbol

psmc1a Nomenclature History

Previous Names

psmc1
wu:fb05d04

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145353 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmc1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss	Alliance	?Birk-Aharoni syndrome	620071

Associated With psmc1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR032501	Proteasomal ATPase, second OB domain
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR050221	26S Proteasome Regulatory ATPase
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase