Gene
herc1
- ID
- ZDB-GENE-030131-8542
- Name
- HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
- Symbol
- herc1 Nomenclature History
- Previous Names
-
- wu:fb14f01
- zmp:0000000833
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin-protein transferase activity. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Macrocephaly, dysmorphic facies, and psychomotor retardation | 617011 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019775 | WD40 repeat, conserved site |
Domain | IPR000569 | HECT domain |
Domain | IPR001870 | B30.2/SPRY domain |
Domain | IPR003877 | SPRY domain |
Domain | IPR035768 | HERC1, SPRY domain |
Family | IPR051625 | Diverse Signaling and Regulatory Domain-Containing Protein |
Homologous_superfamily | IPR009091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
Homologous_superfamily | IPR043136 | B30.2/SPRY domain superfamily |
Repeat | IPR000408 | Regulator of chromosome condensation, RCC1 |
Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
Protein | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | Diverse Signaling and Regulatory Domain-Containing Protein | HECT domain | HECT, E3 ligase catalytic domain | HERC1, SPRY domain | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Regulator of chromosome condensation, RCC1 | SPRY domain | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3BB18
|
4867 | ||||||||||||||
UniProtKB:A0A8M9PPR0
|
4848 | ||||||||||||||
UniProtKB:A0A8M3AU96
|
4860 | ||||||||||||||
UniProtKB:A0A8M9QHR3
|
4859 | ||||||||||||||
UniProtKB:A0A8M3B194
|
4859 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance