Gene

cnksr2b

ID

ZDB-GENE-030131-8048

Name

connector enhancer of kinase suppressor of Ras 2b

Symbol

cnksr2b Nomenclature History

Previous Names

fj48e09
si:dkey-92k1.12
wu:fj48e09 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to be involved in regulation of signal transduction. Predicted to localize to cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnksr2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
syndromic X-linked mental retardation Hough type	Alliance	Intellectual developmental disorder, X-linked syndromic, Houge type	301008

Associated With cnksr2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR010599	Connector enhancer of kinase suppressor of ras 2/3 domain
Domain	IPR017874	CRIC domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	Connector enhancer of kinase suppressor of ras 2/3 domain	CRIC domain	PDZ domain	PDZ superfamily	PH-like domain superfamily	Pleckstrin homology domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily
UniProtKB:E7FAZ0 InterPro	963
UniProtKB:A0A8M3AM98 InterPro	969

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cnksr2b-201 (1) Ensembl	Havana	3352 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cnksr2b-002 (1) Ensembl	Havana	494 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations