Gene
supt6h
- ID
- ZDB-GENE-030131-7949
- Name
- SPT6 homolog, histone chaperone and transcription elongation factor
- Symbol
- supt6h Nomenclature History
- Previous Names
-
- pan
- Spt6 (1)
- pandora
- wu:fj42h11
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have histone binding activity and nucleosome binding activity. Involved in several processes, including negative regulation of histone H3-K27 methylation; otic vesicle development; and somitogenesis. Predicted to localize to transcription elongation factor complex and transcriptionally active chromatin. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Keegan et al., 2002
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR003029 | S1 domain |
| Domain | IPR006641 | YqgF/RNase H-like domain |
| Domain | IPR028083 | Spt6 acidic, N-terminal domain |
| Domain | IPR028088 | Helix-turn-helix DNA-binding domain of Spt6 |
| Domain | IPR028231 | Transcription elongation factor Spt6, YqgF domain |
| Domain | IPR032706 | Transcription elongation factor Spt6, helix-hairpin-helix motif |
| Domain | IPR035018 | Spt6, SH2 domain, C terminus |
| Domain | IPR035019 | Spt6, SH2 domain, N terminus |
| Domain | IPR035420 | Spt6, SH2 domain |
| Domain | IPR041692 | HHH domain 9 |
| Family | IPR017072 | Transcription elongation factor Spt6 |
| Homologous_superfamily | IPR010994 | RuvA domain 2-like |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR023319 | Tex-like protein, HTH domain superfamily |
| Homologous_superfamily | IPR023323 | Tex-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
| Homologous_superfamily | IPR037027 | YqgF/RNase H-like domain superfamily |
| Homologous_superfamily | IPR042066 | Spt6, Death-like domain |
Domain Details Per Protein
| Protein | Length | Helix-turn-helix DNA-binding domain of Spt6 | HHH domain 9 | Nucleic acid-binding, OB-fold | Ribonuclease H-like superfamily | RuvA domain 2-like | S1 domain | SH2 domain | SH2 domain superfamily | Spt6 acidic, N-terminal domain | Spt6, Death-like domain | Spt6, SH2 domain | Spt6, SH2 domain, C terminus | Spt6, SH2 domain, N terminus | Tex-like domain superfamily | Tex-like protein, HTH domain superfamily | Transcription elongation factor Spt6 | Transcription elongation factor Spt6, helix-hairpin-helix motif | Transcription elongation factor Spt6, YqgF domain | YqgF/RNase H-like domain | YqgF/RNase H-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AWY8
|
1728 | ||||||||||||||||||||
|
UniProtKB:Q8UVK2
|
1726 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
supt6h-201
(1)
|
Ensembl | 6,394 nt |
Interactions and Pathways
No data available
Plasmids
No data available