ZFIN is now using GRCz12tu for Genomic Data
Gene
lrpprc
- ID
- ZDB-GENE-030131-7887
- Name
- leucine-rich pentatricopeptide repeat containing
- Symbol
- lrpprc Nomenclature History
- Previous Names
-
- fc13c04
- im:7150924
- im:7151572
- wu:fc13c04
- wu:fj38h02
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mitochondrial translation. Predicted to be active in mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; musculature system; nervous system; and segmental plate. Used to study French Canadian Leigh disease. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151572 (9 images)
- IMAGE:7150924 (8 images)
- IMAGE:7165989 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Sabharwal et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| French Canadian Leigh disease | Alliance | Mitochondrial complex IV deficiency, nuclear type 5, (French-Canadian) | 220111 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| French Canadian Leigh disease | lrpprcmn0235Gt/mn0235Gt | standard conditions | Sabharwal et al., 2022 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich PPR motif-containing protein | Pentatricopeptide repeat | PROP1-like, PPR domain | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A4QNU0 | InterPro | 960 | ||||
| UniProtKB:A0A8N1TT16 | InterPro | 1436 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lrpprc-201
(1)
|
Ensembl | 4,829 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers