Gene
mylipa
- ID
- ZDB-GENE-030131-7831
- Name
- myosin regulatory light chain interacting protein a
- Symbol
- mylipa Nomenclature History
- Previous Names
-
- Mir (1)
- mylip
- wu:fj36b03
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-protein transferase activity. Involved in gastrulation. Located in cytoplasm. Is expressed in several structures, including axis; midbrain; neural plate; polster; and retina. Orthologous to human MYLIP (myosin regulatory light chain interacting protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55987 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43288 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mylipa | N/A | Knowlton et al., 2003 |
| MO2-mylipa | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | MYLIP, FERM domain C-lobe | PH-like domain superfamily | Ubiquitin-like domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TEM9 | InterPro | 472 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mylipa-201
(1)
|
Ensembl | 2,600 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266J17 | ZFIN Curated Data | |
| Encodes | EST | fj36b03 | ||
| Encodes | cDNA | MGC:55987 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77168 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199983 (1) | 2600 nt | ||
| Genomic | GenBank:BX936330 (2) | 79553 nt | ||
| Polypeptide | UniProtKB:Q6TEM9 (1) | 472 aa |
- Li, Z., Li, J., Li, Z., Song, Y., Wang, Y., Wang, C., Yuan, L., Xiao, W., Wang, J. (2024) Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3. PLoS pathogens. 20:e1012227e1012227
- Gao, G., Guo, S., Zhang, Q., Zhang, H., Zhang, C., Peng, G. (2022) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles. eLIFE. 11:
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Vopalensky, P., Pralow, S., Vastenhouw, N.L. (2018) Reduced expression of the Nodal coreceptor Oep causes loss of mesendodermal competence in zebrafish. Development (Cambridge, England). 145(5)
- Zhao, B.S., Wang, X., Beadell, A.V., Lu, Z., Shi, H., Kuuspalu, A., Ho, R.K., He, C. (2017) m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.. Nature. 542(7642):475-478
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Schmitt, C.E., Woolls, M.J., and Jin, S.W. (2013) Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Molecules and cells. 35(2):166-172
- Knowlton, M.N. and Kelly, G.M. (2004) Zebrafish Mir Antagonizes Frizzled 7-Induced Gastrulation Defects. Zebrafish. 1(2):133-144
- Linney, E., Dobbs-McAuliffe, B., Sajadi, H., and Malek, R.L. (2004) Microarray gene expression profiling during the segmentation phase of zebrafish development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):351-362
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
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