Gene

fasn

ID

ZDB-GENE-030131-7802

Name

fatty acid synthase

Symbol

fasn Nomenclature History

Previous Names

FAS (1)
fj34h12
wu:fj34h12

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have several functions, including fatty acid synthase activity; hydrolase activity, acting on ester bonds; and phosphopantetheine binding activity. Involved in response to (R)-carnitine. Is expressed in liver and male organism. Orthologous to human FASN (fatty acid synthase).

Genome Resources

Note

Transcripts from ENSDARG00000087657 in Ensembl GRCz11 are associated with ccdc57 and fasn. fasn-202 (ENSDART00000124982) should be associated with ccdc57. Other transcripts belong with fasn. Alternate gene (haplotype) in GRCz11 is ENSDARG00000113553.

Comparative Information

Expression

All Expression Data

64 figures from 56 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fasn Human Ortholog

No data available

Associated With fasn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018201	Beta-ketoacyl synthase, active site
Domain	IPR001031	Thioesterase
Domain	IPR009081	Phosphopantetheine binding ACP domain
Domain	IPR013968	Polyketide synthase, ketoreductase domain
Domain	IPR014030	Beta-ketoacyl synthase-like, N-terminal
Domain	IPR014031	Beta-ketoacyl synthase, C-terminal
Domain	IPR014043	Acyl transferase domain
Domain	IPR020806	Polyketide synthase, phosphopantetheine-binding domain
Domain	IPR020807	Polyketide synthase, dehydratase domain
Domain	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain
Domain	IPR020843	Polyketide synthase, enoylreductase domain
Domain	IPR032821	Polyketide synthase, C-terminal extension
Domain	IPR049391	Fatty acid synthase, pseudo-KR domain
Domain	IPR049552	Polyketide synthase, dehydratase domain, N-terminal
Domain	IPR049900	Polyketide/metazoan fatty acid synthase, dehydratase domain
Family	IPR050091	Polyketide and Nonribosomal Peptide Biosynthesis Enzymes
Homologous_superfamily	IPR001227	Acyl transferase domain superfamily
Homologous_superfamily	IPR011032	GroES-like superfamily
Homologous_superfamily	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
Homologous_superfamily	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding
Homologous_superfamily	IPR016039	Thiolase-like
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily
Homologous_superfamily	IPR036736	ACP-like superfamily
Homologous_superfamily	IPR042104	Polyketide synthase, dehydratase domain superfamily
PTM	IPR006162	Phosphopantetheine attachment site

Domain Details Per Protein

Protein	Length	ACP-like superfamily	Acyl transferase/acyl hydrolase/lysophospholipase	Acyl transferase domain	Acyl transferase domain superfamily	Alpha/Beta hydrolase fold	Beta-ketoacyl synthase, active site	Beta-ketoacyl synthase, C-terminal	Beta-ketoacyl synthase-like, N-terminal	Fatty acid synthase, pseudo-KR domain	GroES-like superfamily	Malonyl-CoA ACP transacylase, ACP-binding	NAD(P)-binding domain superfamily	Phosphopantetheine attachment site	Phosphopantetheine binding ACP domain	Polyketide and Nonribosomal Peptide Biosynthesis Enzymes	Polyketide/metazoan fatty acid synthase, dehydratase domain	Polyketide synthase, beta-ketoacyl synthase domain	Polyketide synthase, C-terminal extension	Polyketide synthase, dehydratase domain	Polyketide synthase, dehydratase domain, N-terminal	Polyketide synthase, dehydratase domain superfamily	Polyketide synthase, enoylreductase domain	Polyketide synthase, ketoreductase domain	Polyketide synthase, phosphopantetheine-binding domain	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Thioesterase	Thiolase-like
UniProtKB:E7F5V3 InterPro	2514
UniProtKB:F8W3U6 InterPro
UniProtKB:A0A8M9Q0T1 InterPro	724

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fasn-201 (1) Ensembl	Ensembl	7,536 nt	Select Tool ZFIN BLAST
mRNA	fasn-202 (1) Ensembl	Ensembl	8,323 nt	Select Tool ZFIN BLAST
mRNA	fasn-203 (1) Ensembl	Ensembl	10,042 nt	Select Tool
mRNA	fasn-205 (1) Ensembl	Ensembl	281 nt	Select Tool
mRNA	fasn-206 (1) Ensembl	Ensembl	171 nt	Select Tool ZFIN BLAST
ncRNA	fasn-002 (1) Ensembl	Ensembl	485 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations