Gene

slc1a2b

ID

ZDB-GENE-030131-7779

Name

solute carrier family 1 member 2b

Symbol

slc1a2b Nomenclature History

Previous Names

eaat2 (1)
slc1a2
SLC1A2a (1)
EAAT2a
fj34b12
tnt
wu:fj34b12
zgc:65897

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Acts upstream of or within larval locomotory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and spinal cord neural tube. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc1a2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 41	Alliance	Developmental and epileptic encephalopathy 41	617105

Associated With slc1a2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
developmental and epileptic encephalopathy 41	slc1a2b^zh7/zh7	standard conditions	Hotz et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018107	Sodium:dicarboxylate symporter, conserved site
Family	IPR001991	Sodium:dicarboxylate symporter
Family	IPR050746	Dicarboxylate/Amino Acid:Cation Symporter
Homologous_superfamily	IPR036458	Sodium:dicarboxylate symporter superfamily

Domain Details Per Protein

Protein	Length	Dicarboxylate/Amino Acid:Cation Symporter	Sodium:dicarboxylate symporter	Sodium:dicarboxylate symporter, conserved site	Sodium:dicarboxylate symporter superfamily
UniProtKB:D7RVR7 InterPro	523
UniProtKB:A0A8N7UZX7 InterPro	562

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slc1a2b-201 (1) Ensembl	Ensembl	4,291 nt	Select Tool ZFIN BLAST
mRNA	slc1a2b-202 (1) Ensembl	Ensembl	4,033 nt	Select Tool ZFIN BLAST
mRNA	slc1a2b-204 (1) Ensembl	Ensembl	4,217 nt	Select Tool ZFIN BLAST
mRNA	slc1a2b-205 (1) Ensembl	Ensembl	1,637 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000056846 (1) Ensembl	Ensembl	258 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-slc1a2b	polyclonal	slc1a2b		Chicken	IHC		3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations